QCM-D Quartz Crystal Microbalance

QSense instruments - tracking changes at the surface - are based on the patented QCM-D technique. The instruments measure in real-time the mass of molecular layers that form on the quartz sensor. Simultaneously structural (viscoelastic) properties of such molecular layers are monitored, which enables distinction between two similar interactions or observation of a phase transition in bound layers.

The Explorer  from QSense is a compact design QCM-D for one flow module, holding one sensor. It is temperature controlled and samples are introduced by using a peristaltic pump included in the system. An optional electrochemistry cell is available making it possible to combine QCM-D and electrochemistry measurements. A window module is also available for optical access to the crystal during measurements, enabling e.g. a combination of microscopy and QCM-D as well as a Ellipsometry module.


This high-end QCM-D surface analysis equipment is an intuitive instrument and software platform that senses mass change, layer thickness, binding and molecular orientation at the nano-scale. It´s 8-sensor module allows high throughput and makes reproducibility easy. High precision flow-control is ensured by using syringe pumps that work separately and allows four channels to be used independently.

Programing automated mixing including concentration gradients of samples ensures high reproducibility.
Temperatures can be set between 4 and 70 °C enabling stable temperature control. Pre-cooling or heating of sample racks is possible.


For the E-series instruments from QSense there are several modules to combine QCM-D with other techniques such as electrochemistry, ellipsometry and microscopy. Additionally 40 different sensor surfaces are available.


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